Origen DBM with Bioactive Glass is an innovative alternative for promoting bone growth by combining the properties of DMB with the boosting effect of bioactive glass.  Origen DBM creates rapid surface reactions that stimulate the proliferation of bone-forming cells. Because of its compatibility and structural similarity to natural bone, bioactive glass bonds directly to the host bone.  As the dissolution progresses the surface layer increases in thickness to form bone that is completely organic, not foreign, material.  Bioactive glass minimizes the inflammatory response ordinarily associated with trauma and is easily reabsorbed.

• Bioactive glass boosts the activity levels of certain growth factors (IGF-II + VEGF)
• Regenerates tissues that provide bonding characteristics equal to bone¹
• Easily reabsorbed
• Upregulates the process of osteogenesis²

Specifically micro-encapsulated in a porcine gel carrier for improved handling characteristics and provides consistency in absorption. Origen DBM can be mixed, molded and moved without difficulty. Origen DBM is an ideal bone graft composite without the associate risks of autograft harvesting.

• Micro-encapsulated technology improves handling

Origen DBM gives surgeons a better handle on bone grafting procedures through its unique formulation and osteoinductive properties.

1 "Biodegradable and bioactive porous polymer/inorganic composite scaffolds for bone tissue engineering" K. Rezwana, Q.Z. Chena, J.J. Blakera, Aldo Roberto Boccaccinia, b, a Department of Materials, Imperial College London, Prince Consort Road, London SW7 2BP, UK Centre for Tissue Engineering and Regenerative Medicine, Imperial College London, London SW7 2AZ, UK

2 Xynos, I.D., et al. Gene-expression profiling of human osteoblasts following treatment with the ionic products of Bioglass 45S5 dissolution. Journal of Biomedical Materials Research. 2001;55(2):151-157.

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